Postop pathology to ChatGPT & asked about BCR. Anyone done this?
I used ChatGPT for the first time and input my post-op pathology details into it and then asked about recurrence. To my surprise, it stated that for men with “several high-aggressiveness factors” like mine,I.e.,
* Seminal vesicle invasion (pT3b)
* Multiple positive surgical margins
* Cribriform + Intraductal carcinoma
* Gleason 4+3
* Decipher score 0.89 (high-risk)
I should consider “ultra early” radiation therapy. It went on to state that a Sustained detectible PSA as low as 0.03-0.05 ng/mL should be used as a threshold to initiate conversations with your oncologists about radiation early salvage treatment and possibly, ADT. It specifically said,
“ PSA 0.03–0.05 ng/mL and rising (confirmed on two tests)”
And emphasized,
“Do NOT wait until PSA reaches 0.1. Patients with these features progress quickly once microscopic recurrence begins, and outcomes are best when salvage radiation is given at very low PSA levels.”
Referencing the AUA/ASTRO/SUO 2024 Guideline:
* Recommends early salvage radiation when PSA first becomes detectable.
* Strongly favors PSA ≤0.2, but many experts recommend ≤0.1 or even ≤0.05 for high-risk patients.
*
2. Multiple large studies
Consistently show:
* Best long-term cancer control happens when salvage RT is delivered with PSA ≤0.05
* Outcomes are significantly worse once PSA rises above 0.1
* Waiting until 0.2 (the “traditional” definition of recurrence) is now considered too late for high-risk patients.
It went on to explain that while the broad consensus guidance still defines biochemical recurrence at PSA >=0.2 ng/mL, the studies this was based on did not include a statistically relevant number of higher risk patients or account for their specific tendency for greater metastasis velocity.
It certainly puts new emphasis for me on watching my PSA very very closely and I will be discussing with my doctors on the coming weeks depending on the outcome of my next PSA (blood draw on Tuesday 12/16/25).
Interested in more discussions like this? Go to the Prostate Cancer Support Group.
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Oh . And psa up to 4 something from 3.26 @ weeks after surgery.
@wert1234
https://urology.ucsf.edu/sites/default/files/uploaded-files/attachments/p8-ii-diet_guide_web_05232018.pdf
This is what we were given by our doctor at UCSF.
Also, I would strongly recommend these books :
"How to Prevent and Treat Cancer with Natural Medicine" by Michael Murray
it is endorsed by Cancer Treatment Centers of America
I also found those 2 very helpful :
"How to Prevent and Treat Cancer with Natural Medicine" by Rebecca Katz
"How Not to Die: Discover the Foods Scientifically Proven to Prevent and Reverse Disease" by Michael Greger M.D.
My husband is high risk patient also, and BCR is something that is always on our minds (or better said on "my" mind). Sometimes BCR happens no matter what but at least we would know that "we tried". Recommendations in those books are good anyway for anybody, cancer patient or not.
Wishing you all the best and a complete eradication of PC in very near future.
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2 Reactions@wert1234
This link has a lot of information on diet and exercise.
https://cdn.prod-carehubs.net/n1/748e8fe697af5de8/uploads/2025/03/TPCC-diet.pdf
plant based diet is shown to reduce the incident of prostate cancer recurrence
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2818122
I would look at YouTube for PCRI videos that discuss diet.
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1 Reaction@wert1234
Greater than 2.5 can be suspicious for metastatic. I would imagine they’re going to want to do some SBRT radiation on at least some of your lymph nodes,
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1 Reaction@surftohealth88
Thank you for all!
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1 Reaction@jeffmarc
Thanks Jeff