Hi @71young, and welcome to Mayo Clinic Connect. It sounds like you are being proactive to live your best, active life and working with a cardiologist focused on the same thing. You bring up a great question, pinning down the best information to decide if you should switch from Crestor that is working well for you, to Leqvio.

I so wish I could give you a clearly defined answer. I am not a medically trained person but I have taken more than my share of cholesterol lowering medications. I take both Leqvio and statin currently and could not be more pleased.

Here are my initial thoughts:
- Cost: Not saying it can’t happen, but I have not heard of anyone able to get insurance to cover Leqvio if statins will keep cholesterol under control.
- Statins work by lowering LDL cholesterol and by suppressing inflammation, which contributes to plaque buildup in arteries. There are years of data to support this. Leqvio is newer, also in the liver but works differently. I think your doctor would need to tell you how it compares.
- Are there concerns statins may start causing side effects? Again, I think only your doctor can address this concern.

While you wait for others to comment it may help to review what others taking Leqvio are saying. I went to the Blood and Health Support Group and searched for Leqvio. There are seven discussions where you will find others discussing the drug:
- Discussions about Leqvio on Connect
https://connect.mayoclinic.org/group/heart-blood-vessel-conditions/ search=Leqvio&index=discussions

Do you have other health conditions your doctor may be considering? Have you had more detailed blood testing that may be considered in the decision? (maybe APoA1, APoB, triglycerides, liver enzymes, blood sugar)