@beachflyer

My last PSA, done a few minutes before my latest mpMRI was -0.5 ng/ml lower than my previous one.

My 2 year “post biopsy” trend (see attached) indicates a 12.3 year doubling time.

To show how variable PSA can be, check out my two measurements performed 15 minutes apart on 5/15/2024.

They were measured using the same lab method (Beckman Coulter) at facilities 5 minutes apart….6.57 versus 5.87….you can guess which one I preferred 😉

PSA is not cancer specific, and PSA doubling time, PSA density and PSA velocity are only slightly better trend predictors….my urologist likes to characterize mpMRI’s as “notoriously inaccurate”….I can only guess what he thinks of PSA
testing, which is a much worse predictor of progression.

I know a man who’s been on active surveillance for 16 years. His PSA was in the 4-5 range for years and then spiked to 112, only to drop back to (and stay) in the 4-5 range 6 months later and beyond…he continues on AS…so go figure…

For all men on active surveillance, my urologist says the maximum time he allows between biopsies is 5 years…EVEN IF every PCa progression predicting test and calculation is indicating “negative progression”….it’s his way of ensuring that all those “notoriously inaccurate” tests that we on AS so dutifully submit to don’t end up leading to a “strange anomaly”, based on a biopsy.

Looking forward to the day when a non-invasive test is proven more accurate than a biopsy…hopefully not to far in the future.

All the best!