Did gem-abraxane-cisplatin in 2024 for 9 months and then just gem-Abrax for remaining 3 months in 2024. Got 2 chemo treatment a month. Nausea and weakness for 9 months, but it was only for first 3 days after chemo treatment. Developed neuropathy in foot in December, but most of it went away by late January 2025. Cancer free (due to MRIdean radiation tx in October 2024). Got peritoneal cancer in April 2025 and went back on abraxanxe-gem but this was new oncologist and I was put on 3 weeks in a row prob cause my ca19-9 was around 14,000 at the time. I was on it full strength (as opposed to a 60% dosage) from August 2025 - December 2025. Last treatment was Dec.11th. Got very bad hematuria and severe cystitis which I learned from my visit with infectious disease dr can be a rare side effect from gem. I went through that for 3 horrible months before I looked it up myself on internet and found out it was true that gem can cause that. Then Abrax hit me like a ton of bricks and I couldn't walk due to neuropathy and it affected my hands (still not working). I had to tell my oncologist that my consulting oncologist from UCLA said to take a 1 month break from chemo. I also got internal neuropathy which I'm still suffering from. I think the 3 weeks of treatment in a row for that many months was too strong for me and I should have been taken off and switched to 2 weeks per month when i started to show the side effects. I've been off chemo for almost 3 months now and I think my liver lesions are back and peritoneal nodules are growing. I'm looking for a clinical trial mow that offers Zolbetuximab with folfirnox that will address the CLD18.2 protein I have that can cause stomach cancer and I'll do radiation again on tne liver lesions. I'm probably the worst case example of side effects from gem abraxane, so there you have it. I wish you much better luck!!

@casey1959

I was borderline resectable when first diagnosed (age 72) because tumor (just under 3 cms) was touching (but not encircling) the mesenteric vein. At the end of the four months of neoadjuvant chemo, three experienced surgeons could see I was eligible for immediate surgery (without going to radiation first).

I was at the Kaiser Hospital in San Francisco. (Subsequently I exchanged letters with the head of the hospital: she told me they had decided to specialize in hepatobiliary surgeries and patient outcomes had improved.)

I was in the hospital for a week -- no complications. I left without drains or attachments. I went back on chemo (largely gemcitabine) for six months. It was a couple of months before I could walk at my usual speed.