Trintellix (vortioxetine) for Major Depression or possibly Anxiety.

Posted by horowitz71 @horowitz71, Aug 15, 2025

Does anyone take Trintellix for Major Depression or Anxiety?

My doctor recently (5 weeks ago) took me off Zoloft/sertraline and prescribed me the relatively new medication Trintellix (vortioxetine),
10 mg/daily. Along with Parkinson's Disease, I've lived with PTSD most of my life (currently 74 yrs old), was diagnose Bipolar 1 many years ago, and my social anxiety has gotten progressively worse. I went out on my own at age 14 after being severely beaten by my stepfather (my father was incarcerated for four years when I was eleven, and I had been living with various relatives until returning home at age 13). I'm a Vietnam vet, seeing a psychiatrist and neurologist through the VA--a hit and miss situation, especially since the recent staffing changes. I'd been taking Benzos (prescribed as much as 4 mg/day, along with Ambien, for more than 30 years when diagnosed with PD while living abroad). Upon my return to the states, I had a doctor who continued my Benzos--2 mg/daily until relocating to Monterey, CA. The VA does not prescribe Benzos, but my neurologist (outside of VA) prescribed Xanax/alprazolam 2 mg/day (for my Parkinson's) until I found a better neurologist at the Palo Alto VA Hospital--next to Stanford Univ., where I got the head of the school's neurology department to see me, but abruptly stopped Benzos. That was about five months ago. I'm not adapting well at all. Without being active: surfing , playing tennis regularly, and doing martial arts, I've become isolated and nervous/afraid; I have horrible insomnia and am afraid to even leave the apartment unless necessary. I try to go to a H2O class for people with MS and PD, but am no longer able to drive and can only afford Lyft for seniors when I share a ride--doesn't happen often. My psychiatrist understands my situation, but cannot prescribe anti-anxiety meds (prohibited by the VA). I haven't found anybody in my area (through Medicare or otherwise) who will prescribe Benzos). My VA doctor prescribed Trintellix because it "may" have a side effect of reducing my anxiety. It's been five weeks since I began taking 5 mg/day (dr. says if it helps, he will increase to 10 mg.) I haven't felt any difference between the Zoloft I'd been taking and Trintellix. Has anyone taken this medication, and if so, how long did it take to work, and what did you experience? I know that abruptly stopping Benzos is no advised, and even gradually reducing them can be extraordinarily difficult and may take years to adjust even when tapering under clinical supervision. Has anyone tried either inpatient or outpatient treatment for Benzo detox? I don't even know if that is an option for me, but it's difficult for me to make it through each day. I'm nervous, afraid, and have never felt depressed for such a long time as now. I've gotten used to brief periods of depression, but have never suffered major or long-term depression. I know it will end, but currently, life is not much fun.

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Profile picture for joseph70 @joseph70

@mwendt54
Prolonged use of Xanax causing more anxiety is not an opinion, it is fact. Your psychiatrist should know this, but go ahead and keep using the same psychiatrist. That is totally your call to make.

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@joseph70
Just please go away. One size does not fit all. You’re nothing more than a bully and I’d really appreciate you not contact or comment on my posts in the future. I don’t need or desire your judgement or negativity in my life. You know absolutely nothing about me. Focus on your own life instead of making other people miserable.

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Profile picture for mike8 @mike8

@horowitz71

Hi,

Thanks for the reply. It seems you are very self aware including what triggers or eases any symptoms . That's a great capability, as not everyone has that.

Were you taking the benzos daily or as needed?

I know what you mean about benzos largely being safe when used as per instructons.

The reason I mentioned the reinstatement (with option of weaning) was not to indicate danger with them, but only that perhaps the Drs may be more open to resintatement if the ultimate purpose was weaning. Even though that's not the desired pathway , *compared* to abrupt withdrawal, it seems more ideal.

But I don't want to accidentally give the wrong advice /say the wrong thing. I just know from experiences with other meds, abrupt withdrawal can wreak havoc with the CNS.

From what you are saying, the other Dr who did prescribe was further away/no longer accessible? Given they've already seen you in person, do they offer remove consults?

(Also apoligies, I addressed/assumed your name was Dave before, but realised that was another poster's name)

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@mike8 Sorry, Mike: I just "found" your email as I was deleting the couple of hundred mails that had piled up while I was out of the country and not using this email address. As far as self-awareness goes, I've met so many wonderful people during my surf travel adventures around the globe over half a century; And I'm an avid reader, so I stashed away more info than I was ever able to use, although now that I'm an older person, and finally a grownup, it's all coming together. I've been doing lots of trauma work, and that's helped me to get to the root of my old and now unnecessary survival habits. I have a couple of great workbooks I'm currently using: Transforming the Living Legacy of Trauma by Janina Fisher, whose mentors were Bessel Van der Kolk and Gabor Maté, am doing Dialectal Behavior Therapy, also with workbooks. I chose that method over Cognitive Behavior because I'm a socialist, and that's the nuts and bolts of Marxism; simplified, it's a compromise between to opposite feelings which create a rebirth/natality in another direction. The work is easy, but you have to be persistent. Hannah Arendt's works have greatly influenced my life, especially her book, The Human Condition. Now that I have a neurological disorder, I've had time to reflect and grow. Along with being a surfer for sixty years, I'd been studying Chinese martial arts which encompasses the five milenia history and culture of an amazing and ever-expanding civilization. In my daily practice of Tai Chi, I'm deeply rooted in Eastern thought--entirely different from the individualism of Western society, which is one of the many reasons the U.S. collapse was inevitable. Plato said that democracy could never be realized because democratic leaders would always be the best actors and showmen, not great thinkers or statesmen. Proof positive, our prez, and worse, Vance--placed there by Palantir and millions of dollars. Also, we're focused on instant gratification rather than building for future generations, while the Chinese are taught from early on to be cooperative. I was amazed when I was fortunate to have visited. Their infrastructure is light years ahead of ours--thousands of miles of high-speed light rail, cheap, economical electric vehicles, amazing engineering works, an education system that builds generations of people working together for the greater good. Sorry, got off track.

It's also helpful to journal, to put your feelings down on paper: prose, notes, artwork, dreams, what your day was like, the people you met; and I finish each day's entries with gratitude. It's easy to forget what a gift we have being on this planet; And we're only here for a brief moment. As I began to slow down, I gained clarity.

Benzos: When I last visited Brazil, a doctor friend of mine wrote out a prescription for Klonopin and gave me some boxes of samples. When I eventually ran out, I was able to find an online "supplier" called MEDvidi. I pay $159/mo to see a doc writes me 'scrips for
0.25 mg alprazolam which I take only as necessary. They're fast-acting and helpful for my
occasional panic attacks. I'm tempted to take a pill whenever I interpret my tremors as anxiety, but don't, although I feel safe knowing I have one on hand. I'm currently trying water micro-dosing to taper down. Stopping abruptly was nothing short of torture. I was taking 2 mg/day plus 10 mg of Ambien. On top of nausea and vomiting, I ended up having a tia (mini stroke)--lost a bit of feeling down the left side of my body, but it's not a big deal.

So, Mike, please be gentle with yourself as you work on your issues. There's another self inside you that needs love and attention. I hope you connect with that beautiful person and get to share him with the world. Thank you for reaching out to me.

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