My husband did 6 months of folfironox, then a reduced regimen of it until numbers started going up. His cancer had spread to lungs and bones/spine before diagnosis so that part was different than what you describe. Other than hair loss I don't think the abrax/gem was as debilitating with side effects, however unfortunately it did not work for him. The oncologist had an experimental drug that he was going to try next but his cancer got him first. Other people on this forum have had success for many, many months/years with gem/abrax so I am wishing the best for you.