@pmom3366 They are currently in phase 3 trials of a couple of new estrogen blocking drugs. They are called SERD's, selective estrogen receptor degraders, a whole new approach it seems, compared to the AI's. They end in the name estrant, Giredestrant and Elacestrant are a few that I have heard of. From what I have heard and read about them so far, they seem to be claiming they have less side effects or so called better patient tolerance compared to AI's. It's kind of hard to imagine they would create anything new that is worse than AI's, after being on them for 3 years now, they have ruined my life. Of course anything new, you can't possibly know long term side effects until years from now. We all know that WE are the real guinea pigs who do the testing of these drugs. Hopefully, God willing, they will be better and help women like us to have a better option.