I was started on Hydroxychloroquine last fall and the first month was a bit rough, nausea, diarrhea mostly. I was taking it in the mornings, so started taking it at night. That was better, but I have noticed that if I take it right before bedtime, it seems to make me less sleepy so I am adjusting to early evening. I was recently diagnosed with chronic gastritis after an endoscopy, and I'm losing considerable weight. However, these symptoms started before I started on hydroxycoroquine so I don't think it's that. The trade-off is that it has noticeably improved my Sjogren's symptoms and arthritis. I am willing to try to work with this while it's so effective, the other meds apparently have more bothersome side effects. Hydroxychloroquine needs to be taken with food and I take a low dose. I can relate to your reaction to meds, I do that as well, always take a lower dose of things even like Tylenol or NSAIDS when I use them.