Try miralax and magnesium citrate powder mixed in large glass of water about three hours before bed followed by drinking two more large glasses of water before bed. Yes you may have to pee during the night but it may help. Continue your Linzess. Get up at same time every am and take with a lot of warm water and then move around for a Half hour then eat. No white bread or soft wheat bread only sprouted grain like the Ezekiel bread kept in the freezer. No cheese. I do lactose free milk and I make my own yogurt with lactose free kefir and I mix defrosted frozen cherries in it. Good fiber. I do fiber gummies too. I eat my dinner at lunch and then in the evening eat light like a bowl of steal cut oats and an apple or salad. . Something healthy. There are others meds besides Linzess. Talk to your GI DR. You can also try the relatively new thing for constipation called the Vibrant Capsule but it has a tiny battery bins it so once you start you CAN NOT get an MRI. It is working for me. It stimulates the normal movement of your intestines. I do the miralax and Mag mixture at 6:30 and the Vibrant cap at 7:30. I go to bed at 9 and wake of without fail at 5 am and take my Linzess with very warm water. I use to have to drink like 7 cups of water with it now I only have to drink two 20 ounce glasses of warm water with it. It’s a royal pain in the ass to do all this BUT it works. I have no to minimal movement and adhesions in my colon. I do exercise, and am active, eat healthy and drink a lot of fluids. This regime isn’t for everyone. My GI appointment is coming up soon and I may talk to my GI Dr about switching my Linzess but I finally am getting my Linzess for free from Abvie. I’m on Medicare. Regarding switching RX CIC meds, Montegrity comes in generic but has a lot of side effects that Linzess doesn’t have like psychotic issues, like suicidal thoughts ,you should not take if you have any Hx of depression and mental illness. There are other meds but all super expensive unless you have a premium RX insurance plan. Also consider side effects. My hope and contentment in life isn’t based on my physical well being or circumstances but my hope is in God. Ask him to guide you and give you wisdom I dealing with this. Look up, not down. No man is a mountain so do go it alone. I pray you find what works for you. Always let your Gastroenterologist know what you are doing and what your needs are. We don’t all fit into the same mold. 😊

@emoecurly - welcome to Mayo Clinic Connect. I wanted to let you know I've moved your post here to this existing discussion so that you could meet others talking about IBS-C:

- Treating IBS-C https://connect.mayoclinic.org/discussion/treating-ibs-c/

Glad to see you got some input from @bb03. Hoping others in this discussion such as @mark1952 @phxbarb @researchmaven and others also will chime in with what has helped them with IBS-C.

Do you see a gastroenterologist you trust, emoecurly? What does he or she suggest you do at this point for treatment?

@emoecurly

It is great that taking some meds/OTCs actually helped you for a while. Not everyone has such luck. I haven't read that you have tried changing your diet. Or certain foods may no longer move well in your gut and therefore cause IBS-C. What you eat and how much of what you eat, might be a factor for you now.

Or, could you have changed your diet in such a way to sabotage your meds/OTCs? For example, melatonin and CoQ10 turn my gut into concrete. Maybe you are taking something that triggers IBS-C for you.

I also got on top of my stress/anxiety with the help of a gut/CBT therapist. Seven weekly sessions and I learned/practiced how to calm down. It was so worth it. Being calmer is part of my IBS-C solution.

Hopefully reading posts on this site and doing your own web searches will give you some new things to try. An earlier post, detailing my health practice, is above.