Yes it can. I was on it many years and started having 6 months of terrible shaking, and almost the inability of writing my name. Then .a black box warning just came out stating the severe side effects you mentioned and that they may be permanent. I tried domperidone from Canada which helped but then used the erythromycin that my insurance paid for (125 mg 4 times a day as a prokinetic---stomach contraction). I was lucky that all the shakiness abated but took many months. It is very serious. AS a nurse, we used to use it on infants who had reflux. I never knew it had such severe side effects and like I said, I took it at least 6 or 7 years before it became so bad. NEVER again! Tardive dyskinesia is a horrible side effect that I have had patients with and I thank God I did not get that. The uncontrollable shakiness was enough. It almost was to the point I had to sign an X. My neurologist was so thorough always reviewing all my medicines and was the one who found the NEW alert!