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Has anyone used the oral medication for dry mouth (Sjogren's)?
Autoimmune Diseases | Last Active: Mar 18 6:52am | Replies (59)Comment receiving replies
Pilocarpine seems to be working most of the day for me. I just started it 2 weeks ago. I haven’t been diagnosed yet for Sjoren’s because the bloodwork doesn’t show it. It does show ANA positive and high Centromere, but that’s for the Raynaud’s syndrome I have. I have had unbearable dry mouth since November, 2025 and tried everything. I do have a Rheumatologist because of my Osteoperosis treatment, the ANA positive with Centromere. I was told that it could be a false negative for Sjogren’s right now, but may show up later on.
Replies to "Pilocarpine seems to be working most of the day for me. I just started it 2..."
@kellen I have been using Zylamelts for the past couple of years and they seem to help a lot at night. I’m sure you could use them during the day as well if needed.
@kellen I had positive ANA and CCP along with some low blood counts. My rheumatologist did an 'Early Sjogren's Profile Panel ' on me because I have all the symptoms of Sjogren's but don't test positive on the traditional anti-SSA, SSB tests, which according to him often won't be positive until there is advanced damage. The early panel was developed to help with an earlier diagnosis, but it's not relied on for an official diagnosis of Sjogren's. My rheumatologist has been great in that he is more concerned with treating the symptoms and inflammation and is quick to acknowledge that the tests aren't always able to detect the antibodies. Sjogren's is a tough one to diagnose apparently.
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@kellen I have heard that Sjogren's it hard to diagnose. My dry mouth is also unbearable! I did hear that taking Pilocarpine could cause sweats. I hate taking anything...especially if there are nasty side effects. If it improve my dry eyes, I might take it. I feel desperate. It has gotten worse every year.