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DiscussionWhat treatment for neuropathic itch from chemo worked for you?
Cancer: Managing Symptoms | Last Active: Jun 4 9:25am | Replies (24)Comment receiving replies
Replies to "@beebe i thought gabapenten and lyrica were the same thing"
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@sart
Lyrica is a brand name for pregabilin and is classified as a schedule 5, controlled substance, whereas gabapentin is not. The following is from a substance abuse website:
People often wonder why Lyrica (pregabalin) is a controlled substance while the similar medication gabapentin (sold under the brand name Neurontin) isn’t. The drugs are both analogs for the neurotransmitter GABA, are prescribed for largely the same conditions (epilepsy and neuropathic pain), and have the same side effects (fatigue, dizziness).
The answer is that pregabalin is more rapidly absorbed, has a higher bioavailability, and is more potent: two to four times as strong as a pain reliever and three to 10 times as potent as an anti-epileptic.[7]
Additionally, studies suggest that pregabalin is more likely to produce behavioral dependence. In a review of case studies of gabapentinoid abuse, symptoms of behavioral dependence—including cravings and drug-seeking—were found in 79% of studied users of pregabalin, compared to just 8% of studied users of gabapentin. However, most of the users included in the study had pre-existing or concurrent substance abuse issues, and the study authors concluded that in the general population, both gabapentinoids are “quite rarely addictive.”[8]
However, gabapentin, like pregabalin, does also have the potential for abuse among people with substance abuse issues, especially addictions to heroin and other opioids. Some jurisdictions, especially those hit hardest by the opioid crisis, have tightened controls on gabapentin accordingly. Alabama, Kentucky, Michigan, North Dakota, Tennessee, West Virginia, and Virginia have all made gabapentin a Schedule V controlled substance at the state level.[9]