63 year-old male, previously very healthy and active. I had a complete nephrectomy of my right kidney in December 2024, with a diagnosis of Stage 3a CCRCC. After 12 weeks of healing, I started IV infusions of Keytruda 400mg every 6 weeks. First reactions were tingling/numbness in my fingers and hands, fatigue, and joint stiffness. Each successive cycle of immunotherapy has either added more side effects or upped the level of intensity of the side effects I already had. I also haven’t slept through the night since before my surgery.

Other side effects have been itchiness, brain fog, diarrhea, nausea, and irritability. Since I’m a dentist by trade, I’ve been unable to work with the neuro affects to my hands and fingers. Fortunately I have a Long Term Disability policy that kicked in. Latest side effect is severe knee pain when I crouch down and try to stand back up.

On the positive side, I have been allowed to travel because my immune system is turbocharged, not suppressed. Meds have helped with pain, nausea, and diarrhea. And the side effects are worth it because the Keytruda will increase my 5 year survival rate by 7% or so. I’ll do whatever I can to keep going.

Feel free to contact me directly if you want to get more details. I’m happy to share my experience with anyone who is going through, or thinking of going through, the same