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@lamer25
One thing that can beat the fatigue is to exercise, walking, Running doing weightlifting can be really good for the fatigue and prevent the borne deterioration and muscle deterioration the drugs cause. It does seem counterproductive, but it works for almost everyone.

As for the joint pain, You should speak to your doctor about this and maybe try to get a palliative care doctor to work with him to resolve the problem. I take gabapentin and it works for me, but it is something you need a prescription for so you need to talk to a doctor and see what they recommend.

I’ve been on ADT for eight years and I’m 78. I have no fatigue really but I run a mile twice a day on a track and go to the gym three days a week to do weight training.

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@jeffmarc

Everyone is different. At age 82 my side effects were absolutely horrible, and I believe that an additional month of Lupron beyond 4 months would have killed me. Soaking cold sweats 24 hours/day, 24 hour/day migraine headaches, pain in my bones and joints, frequent urination, no libido, and brain fog. Started with PSA = 11 and Gleasons of 3 ea. 3+4 and 1 ea. 4+4. Six months after 44 radiation treatments and 4 months of Lupron my PSA has been undetectable, and my testosterone has risen to 122 from < 8. Side effects just started to wane 6 months after stopping Lupron. I have always exercised hard at least 4 days/week and still do but had to reduce my speed on the treadmill from 4 mph to 3.3 mph at 10% incline for 40 minutes.