← Return to High Turnover Help - Understanding my CTX/P1NP Ratio

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Profile picture for mcchesney @kathleen1314

@br03
Sorry more clarification:
Have you already had bloodwork done to check your Vitamin D and Parathyroid Hormone (PTH) levels to rule out those common drivers of high bone turnover?

That fracture could be driving elevated bone numbers or secondary causes which I am assuming your endocrinologist is investigating. Discuss with your doctor if high turnover might be driven by other factors like hyperparathyroidism, thyroid issues, or Paget’s disease, especially given the very high absolute values.

Basically, you are ruling out causes and then you will be left with a clearer idea of how to proceed.

Also....
As the body heals a fracture there is frequently something called : The "Fracture Effect": A bone fracture significantly spikes both resorption and formation markers as the body attempts to repair the damage. P1NP and CTX typically peak around 6 to 12 weeks post-injury and can remain elevated for up to 6 months. Since your fracture was in late October, your current high levels may largely reflect this active healing process.

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Replies to "@br03 Sorry more clarification: Have you already had bloodwork done to check your Vitamin D and..."

@kathleen1314 Thank you for sharing this information. I wasn’t familiar with the “Fracture Effect,” but it makes a lot of sense. I’m currently working through lab testing to better understand the root cause. I know it’s not hyperparathyroidism, and my vitamin D levels along with several other micronutrients are in a good range.

I suspect this may be connected to my ongoing gut issues. I recently completed a GI-MAP test and am waiting on those results. My goal is to manage this without medication if possible, so I’m diving deeply into the research to better understand my options. I’m truly grateful for this group, I’ve already learned so much from everyone’s shared experiences.