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High Turnover Help - Understanding my CTX/P1NP Ratio
Osteoporosis & Bone Health | Last Active: Apr 1 10:47am | Replies (27)Comment receiving replies
No, not taking any osteoporosis medications. I had a recent vertebral fracture T 8/9 in late October which is what started this whole process of getting the DEXA and discovering I have severe osteoporosis.
Replies to "No, not taking any osteoporosis medications. I had a recent vertebral fracture T 8/9 in late..."
@br03 Did you ever find out why your markers were high? Mine are very high as well. My CTX is 1,340 and my P1NP is 87. I don't have any fractures. I had prior breast cancer six years ago. My Vitamin D and PTH are normal. I have osteopenia with my left femoral neck on deca at -1.4 and lumbar spine at
-1.8. I also have chronic kidney disease stage 3b. Does anyone have any idea why my markers are so high?
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@br03
Sorry more clarification:
Have you already had bloodwork done to check your Vitamin D and Parathyroid Hormone (PTH) levels to rule out those common drivers of high bone turnover?
That fracture could be driving elevated bone numbers or secondary causes which I am assuming your endocrinologist is investigating. Discuss with your doctor if high turnover might be driven by other factors like hyperparathyroidism, thyroid issues, or Paget’s disease, especially given the very high absolute values.
Basically, you are ruling out causes and then you will be left with a clearer idea of how to proceed.
Also....
As the body heals a fracture there is frequently something called : The "Fracture Effect": A bone fracture significantly spikes both resorption and formation markers as the body attempts to repair the damage. P1NP and CTX typically peak around 6 to 12 weeks post-injury and can remain elevated for up to 6 months. Since your fracture was in late October, your current high levels may largely reflect this active healing process.