@nan2021
Well according to Metagenics which makes SPM:
"Specialized Pro-resolving Mediators (SPMs) are advanced dietary supplements derived from omega-3 fatty acids (EPA/DHA) that actively "resolve" inflammation rather than simply suppressing it. They assist the immune system in clearing debris, reducing chronic inflammation, and promoting tissue repair, often used to support joint health, cardiovascular function, and post-exercise recovery. "

Copilot has suggested based on some research that a baby aspirin taken with the SPM might up the effect of resolution and helping control inflammation. Aspirin can be iffy so best to ask your doctor and if you are taking omega 3s watch to make sure that you aren't thinning the blood too much.

But I prefer this description which I use:
SPM is what your body makes naturally from omega 3 and is used to help resolve inflammation in the body. The problem is that with age ( I know), with stress or disease, the body does not produce SPMs as well or as much, as needed. So supplementation may be needed.

Many people then ask, can't I just eat fish and take omega 3, that is cheaper than buying SPM. Well, then we run into that quandry that age, stress, illness makes it hard for you to convert to SPM or even produce enough so supplementing with SPM gives the body some help.

Personal Example, SPM has helped me and yet my body shows a large amount of omega 3s in my blood work. I eat a lot of fish and take omega 3, but still SPM supplementation helps me.