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@jeffmarc When @copyman mentioned 5 sessions of proton that has to mean proton radiation administered in an SBRT format, right? That's the only way that you could get so few sessions. But if the trial is more concerned about comparing just proton to photon radiation, I suppose they could apply proton radiation in the same low dose way as photon IMRT radiation is applied in 25 sessions. That wouldn't be much of a trial as that would guaranteed work. But maybe the trial is intentionally wanting to test gentle proton radiation in a 5 session high dose SBRT format in order to see if that approach reduces the risk of toxicity when SBRT is applied in this way?

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@wwsmith
The normal way to do proton radiation is in 39 sessions like IMRT. Doing it in five sessions like SBRT and then adding HDR to it sounds to me like a really good trial. That is something they are doing now with SBRT for more advanced cases.

Definitely looking forward to what the results are, Unfortunately, it can take 10+ years to get the real feedback. The thing is, it shouldn’t take much to find out that it does work, I guess the question is do you get the same benefit of minimal damage to other tissue from just doing the one HDR session? Sure sounds like that’s what they are trying to find out, as you surmise.