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Support for wives with the Orgovyx tornado: Needing an olive branch
Prostate Cancer | Last Active: 14 hours ago | Replies (47)Comment receiving replies
My husband has been on Orgovyx and Aberiterone + prednisone for a little over a year. Had proton Therapy in Nov/Dec 2025. Proton therapy great. He has been angry about the Orgovyx since the beginning effects, which were not clearly explained to him by the oncology urologist - who we have since replaced. I totally understand and agree with what you are experiencing and am going through the same experience. Oncologist wants him to continue with both prescriptions for another 2 years. Husband is saying 1 year. We'll see. He insists he is not depressed and will not take anything prescription to help. Says he is taking too many prescriptions as it is - has some other issues. We do take several excellent supplements to support our health, and one that stands out as helping him a lot with mood and temperament is Bliss. He'll take that every day without issue or 'conversation'. I can help with that. Good luck to you both. It's hard. Sometimes just have to go silent and walk away, as nothing I can say or do makes a difference. There's as song, "You only hurt the one you love" that runs through my mind on occasion. My husband apologizes, but that doesn't make it any easier in the moment either.
I am appreciating the comments and help that the men have been offering on this for you.
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@bms39
Please be careful with the supplements, Check with your doctor to make sure they are not going to counter the effects of the drugs he is on. One of the other wives talked about how her husband supplements were causing him to have liver problems and had to stop the supplements right away because they conflicted with the prostate cancer drugs.
You are new here so I’m gonna give you the full list of issues with Orgovyx (ADT)
Due to their different mechanisms of action. ADT which includes Orgovyx, Firmagon, Lupron, Eligard, Prostap, Camcevi, Lucrin, Zoladex, Trelstar, Pamorelin, and Decapeptyl can cause numerous side effects. Actually due to a lack of testosterone.
Hot flashes
Fatigue
Muscle deterioration
Bone weakening
Brain fog
Depression
Weight gain
Joint pain
Difficulty in breathing
Not all of these side effects occur to everyone on the drugs. Most of them are just things you have to be aware of and circumvent. I run on the track twice a day, 1 mile at least, to help prevent bone weakening, fatigue and muscle deterioration. I also go to the gym three days a week (usually) and spend an hour with all different types of weight exercises. One thing that happens is people get a beer belly from the muscle deterioration, I do a lot of sit-ups to offset that.
Some people get depression but it is not common. It is easily treatable, according to people that have reported it on here and on Online Meetings I have participated in. If he has that problem Come back and ask for help, Or see a psychiatrist about doing something to relieve the depression. In some cases that are just mood changes that are not good, Not depression, Exercise can help offset this, Seems counterproductive, but it’s true.
Some people get no hot flashes at all. Others only have a few hot flashes and they are very minor. I had severe hot flashes for the first year on Lupron. As a hot flash was hitting I would feel a lot of fatigue. After a year, my oncologist prescribed a depo-provera shot every three months and it really stopped those hot flashes on Lupron. There are other hormones that can do this, speak to your doctor. If you have this problem, we can give you a list of drugs that can stop it. Ae doctor at a recent conference, put out a big list
I know one person that says eating tofu every day really controlled his hot flashes, another person in this forum said the same thing. Tofu does have properties similar to endocrine hormones but a lot weaker. Can’t hurt to try it. Seems they ate it daily.
According to a doctor that spoke to a recent webinar, many people on ADT, if they are staying on ADT for an extended period or have become castrate resistant should be taking bone straighteners. I took Fosamax for six years and I’m now on Zometa. That along with calcium taken daily helps keep your bones strong. Ask your doctor about this.
I have never gained any weight while on ADT. I get on the scale every morning and base what I eat on what I weigh. Skip lunch at times. Some people gain a lot of weight. The average is 5 pounds but some gain more and some gain none..