@cdammen The short answer is no. But I hear your concerns. For now I will stick with the half-dose of Tam which I assume carries less risk. But I plan on getting a 2nd opinion from a different oncologist in the next few months. It's such a gamble in every way. The AI's carry their own negative risks. So, for me, the 10 mg of Tam is the lesser of the 2 evils for the time being.