@jeffmarc Thanks, Jeff! I've been taking Mirabegron (Myrbetriq) 50 mg unsuccessfully for urinary frequency, as well as having hot flashes. My urologist is considering 5mg Oxybutynin BID for both urinary frequency and hot flashes, but mentioned potential side effects of dry mouth, constipation, and cognitive loss. He commented that if Myrbetriq had been working well, he would have added venlafaxine for controlling hot flashes. I'm typically up at night 4-5 times, with 2 or more of those accompanied by hot flashes as well as throughout the day.