@kathan55 Anything over 1:40 is considered positive on ANA and studies seem to show that the level of ANA doesn't always reflect the level of symptoms; it can however indicate how much it's progressed and will progress going forward. Some autoimmune related diseases won't have a positive ANA. Having a positive SS is usually a strong indicator for Sjogren's, the test has a fairly high false negative rate unless the Sjogren's has caused enough damage to register positive. It's worth pursuing, a good doctor will sit up and pay attention to your clinical symptoms as much as your test results. You are not being a hypochondriac, like many with autoimmune conditions, you're having to study and advocate for yourself. My ANA has been 1:80 and SS negative but an elevated CCP, a positive for the HLA-B27 gene and obvious symptoms prompted my rheumatologist to start me on Hydroxychloroquine for Sjogren's and RA.