@panarosmith I’m finding through this Mayo Connect that many oncologists (including mine) do not provide a full picture of what patients might face on various treatments. There seems to be a basic treatment protocol for post-menopausal women with HR+ tumors. It’s understandable that docs don’t want to plant notions of pain or suffering with AIs; still, I think I could have chosen better for myself with more professional input. Best wishes for smooth sailing and cancer-free times ahead!