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Profile picture for Jeff Marchi @jeffmarc

IMRT followed by HDR Brachytherapy is somewhat common. It makes sense they would try it for SBRT as well. SBRT is not supposed to work too great with cribriform. Including HDR brachytherapy, After SBRT, would make a lot of sense to try.

Must admit this is not something I have heard about in this forum. Some people have discussed doing salvage SBRT but there were some real issues.

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Replies to "IMRT followed by HDR Brachytherapy is somewhat common. It makes sense they would try it for..."

@jeffmarc
Thanks for the reply Jeff. Just to be clear adding HDR Brachytherapy with SBRT or Proton would be good if someone has cribriform? RO also mentioned HT like Lupron could be added for up to 18 months.

@jeffmarc When @copyman mentioned 5 sessions of proton that has to mean proton radiation administered in an SBRT format, right? That's the only way that you could get so few sessions. But if the trial is more concerned about comparing just proton to photon radiation, I suppose they could apply proton radiation in the same low dose way as photon IMRT radiation is applied in 25 sessions. That wouldn't be much of a trial as that would guaranteed work. But maybe the trial is intentionally wanting to test gentle proton radiation in a 5 session high dose SBRT format in order to see if that approach reduces the risk of toxicity when SBRT is applied in this way?