The drugs you are taking are the best. I’ve had prostate cancer for 16 years, Four reoccurrences, And I’m on Orgovyx And Nubeqa the last 3 years, Just like you. It has kept me undetectable for the last 27 months since I had a metastasis zapped on my spine. Nubeqa doesn’t pass the blood brain barrier so it doesn’t cause brain fog and doesn’t cause fatigue for almost everybody. A great drug and no side effects.
The thing is while you can stop Orgovyx As long as your testosterone is down, it will usually take at least three months before your testosterone can hit around 250. A lot faster than leuprolide. Orgovyx has a 25 hour half-life.
The real question is do you have large cribriform? It is much more aggressive than Small cribriform. A lot of doctors will put exactly what type it is in your biopsy, but not all do it. Large cribriform is larger than .25 mm. According to UCSF doctors, in one of their meetings, large cribriform Is equivalent to having a five in your Gleason score.
Your radiation plans sound ideal and it’s good to hear you’re not having much of the way of side effects from ADT.
@jeffmarc, thank you. Unfortunately, mine is large cribriform and the second opinion read on my biopsy slides was performed by Jonathan Epstein, so I’m sure it’s right. I did not know about that level of elevation of the grade that you mentioned……great.