← Return to Decipher risk: prostatectomy RP vs radiation.

Discussion
fritzo avatar

Decipher risk: prostatectomy RP vs radiation.

Prostate Cancer | Last Active: Mar 14 11:09am | Replies (75)

Comment receiving replies
Profile picture for fritzo @fritzo

@wwsmith Sobering, but important information.
I punched in my numbers into that site and it looked better than I expected. It showed survival rate at 15 years at 98 percent. Progression free probability at five years being 77 percent. Progression free probability at 10 years being 64 percent.

So, reading into that, the stats say I'll likely live 15 years(!), but have a 23 percent chance of recurrence in the next five years and at 10 years a 36 percent chance of recurrence.
So, it's very possible that I will have recurrence.

Is there a tool like this for estimating recurrence risk for IMRT?

I wasn't able to follow the inspire link without signing up. Is that a good site for more information? Thanks so much!

Jump to this post


Replies to "@wwsmith Sobering, but important information. I punched in my numbers into that site and it looked..."

@fritzo I am not aware of a similar nomogram prediction on recurrence after radiation treatment. I think such a nomogram would be more difficult to create because there are so many radiation types (IMRT, SBRT, LDR brachytherapy, HDR brachytherapy, and combinations of these) along with various time lengths of ADT involved. As an example, in my own case I had 26 IMRT sessions, one HDR brachytherapy session and one year of ADT.

The side effects from an RP are harsh, immediate, and often long lasting. Those of us choosing radiation as a primary treatment want to avoid those severe side effects and typically choose an aggressive radiation plan such that the odds are good that primary radiation is the only treatment we will need for life. But even if that didn't happen, as @brianjarvis mentioned there are numerous treatments that can follow radiation if need be, even radiation itself. SBRT can be used as spot radiation multiple times where ever needed. All the focal therapies can be used on metastatic spots as well. What can't be done twice is wide area radiation across healthy tissue that has already been radiated. But a recurrence after radiation as a primary treatment is not likely to need that. And if a systemic treatment were needed for a recurrence after radiation as a primary treatment, there are the new drugs like Nubeqa and new procedures like Pluvicto. According to @jeffmarc there are also numerous new treatments under development right now that will be even better than what we have today. As such, I think it is an outdated knock on radiation as a primary treatment that follow-up treatments are limited.

And yes, joining the Inspire cancer forum is very worthwhile. It allows for lengthy blogs as you can see mine here https://www.inspire.com/m/williamwattsmith/about/