@erinhastedt
Well, what I see seems to be tied to the condition for whichyou are taking LDN and how it is tied to your general health situation. Usually, the patients that take LDN have a long term problem that their body just doesn't seem able to reset on its own and the body seems to not be able to hold the reset because of age, disease, inflammation etc . So this becomes a long term use of LDN.

The google search which I did says:
"Low Dose Naltrexone (LDN) is generally considered a long-term maintenance therapy rather than a one-time "reset" for the system. While it recalibrates the immune and neurological systems to promote balance, it does not typically provide a permanent cure for chronic or autoimmune conditions

Key Considerations for Duration
Maintenance vs. Reset: LDN works by temporarily blocking opioid receptors, which triggers a "rebound effect" of increased endorphin production. Because this effect is temporary (the medication clears the body in about 24 hours), daily dosing is usually required to maintain consistent immune modulation.

Discontinuing Use: Many patients report that symptoms—such as fatigue, pain, or inflammation—return within days or weeks of stopping the medication. For this reason, many continue treatment indefinitely as long as it remains beneficial.

Trial Period: Experts often recommend staying on LDN for at least 6 to 12 months to fully assess its impact, as maximum benefits for some conditions may not appear for 8 to 18 months.

"Drug Holidays": Some patients take short breaks (3–7 days) to manage potential tolerance or assess their baseline symptoms, though this should only be done under medical supervision.
https://ldnresearchtrust.org/there-time-you-should-quit-low-dose-naltrexone-ldn.
https://agelessrx.com/how-long-do-you-need-to-take-ldn/.