Dear Elaine,
I'm glad your GI is recommending Entyvio, I've have had no side affects or any adjustment period at all. The Entyvio has completely controlled my diarrhea, but I still have severe cramping and nausea once in awhile. It sometimes takes a few months before you feel better. I hope this answers your question.
Best regards, Carol

@piemonte the alternative to budesonide my GI chose was a low dose azothaprine which is used for chemo patients. I tried it twice from a few days to a week and kept throwing up. Let us know how your appt goes today.

@piemonte Interesting. My initial 90-day course of Budesonide worked great (when I was first diagnosed via biopsy) and I stayed in remission for 6 months or more. Then back on another 3 month round. Again, the same results. Seems the positive results lasted about 6-8 months before relapse. This time, when I decreased to the 6 mg after 30 days, I found it was not working. A new D.O. Gastro Doc said to go back to 9 mg for another month.

I am concerned that I may have to go to a biologic. I was tested and told I do not have celiac disease, that I shouldn't worry about what I eat, but that NSAIDS and alcohol may be triggers. Do biologics work if your disease is autoimmune?

@piemonte How did your appointment with the GI go, Elaine?

Have you changed your diet? I had lots of success with the paleo diet. No gluten, no processes sugars, no sweeteners, no white flours, etc. Grocery stores are getting better at carrying GF bread, even Texas toast! GF corn & rice spaghetti, sandwich wraps, etc. If you haven't read Wayne Persky's books, Microscopic Colitis and the Microscopic Colitis Diet book, I encourage you to read it.