Connect
← Return to Anyone had success with Low-Dose Naltrexone for PEM, Chronic Fatigue?
Discussion
Anyone had success with Low-Dose Naltrexone for PEM, Chronic Fatigue?
Post-COVID Recovery & COVID-19 | Last Active: Feb 22 4:52pm | Replies (28)Comment receiving replies
Yes, I've been on a very low dose for about a year and have found that my PEM is lessened when I am on it. I had to go off of it for a surgery and noticed a difference. It did take a while to work, a few months, and the initial side effects almost made me quit (nausea and dizziness), but in the end, it is worth it. I'm sure others can attest to this, but it doesn't work for everyone, and everyone has different side effects and tolerance levels. I hope it works for you!
Replies to "Yes, I've been on a very low dose for about a year and have found that..."
@erinhastedt - Thank you for sharing your experience.
Connect
@erinhastedt
Yes, LDN is one of those drugs that when it works it can be amazing.
It basically, does a reboot nightly of the immune system which helps reset all the normal parameters which have been messed with my virus action, age or even vaccine impact:
Low-Dose Naltrexone (LDN) improves Post-Exertional Malaise (PEM) and Chronic Fatigue symptoms through three primary pathways that "recalibrate" the body's response to stress and activity, the last link below tells how the below occurs:
1. LDN acts as a glial modulator to inhibit the release of inflammation markers.
2. Helps restore cellular energy
3. Boosts natural endorphins
Research articles:
https://pmc.ncbi.nlm.nih.gov/articles/PMC6954765/.
https://www.painspa.co.uk/low-dose-naltrexone-could-treat-long-covid-symptoms/.
Great paper on how LDN works in the body to help with Long Covid and auto-immune diseases:
https://meassociation.org.uk/wp-content/uploads/MEA-Summary-Review-Low-Dose-Naltrexone-LDN-in-MECFS-14.11.19.pdf