Last year I switched from biweekly IV chemo to capecitaben (caplets). Was an improvement over biweekly IV but after a moth or so hands began drying out, cracking, Feet began drying out. Skin cracking. Interfered with guitar playing. Standing in shower (had tile floor and I could feel every joint). Three weeks ago I returned to IV and symptoms have started to go away. Dr suggested Utterly Smooth hand cream. Has urea acid in it which might help.