Unfortunately, dvargo, I had (most of) the fractures pre-Tymlos/Evenity. The first was c. 2017, and my last occurred about the time I started Tymlos in 2022. After meds, my DEXA numbers improved greatly.

And here's a new wrinkle: Due to insurance changes, I have a new rheumatologist, very interested in OP, whom I visited at the end of January. I had an extensive interview with the doc where he imparted a great deal of wisdom about OP. This doc seemed determined to try to find the reason(s) behind why I have OP and I wasn't going to stop him! In his pursuit, he ordered a complete, and I mean complete, blood panel and 24-hour urine test.

My labs all came back normal but my urine test indicates that my kidneys, while they are functioning well, are excreting too much of the wonder-mineral - calcium - which is perhaps the root cause of my osteoporosis. In over 15 years of knowing I have OP, dealing with potentially problematic drugs and, in spite of my constant questioning, this is the first doc that ever cared about the WHY! My previous doc in his famous 5 minutes of "how are you" and 15-minutes of "how he is" pretty much said, "what difference does it make", you have OP.

Additionally, I should report that my CTX and P1NP numbers went wacky beginning in 2025 and subsequent labs showed my numbers were getting worse, much worse . . . like that's impossible, needs intervention worse. The opening salvo was "Prolia" which I have been fighting tooth and nail (thank you @gently). A new doc, new labs, and suddenly my numbers are back in line with the ones taken post-Evenity.

Hopefully, with a newly-prescribed med, my kidneys will stop sending that much-needed calcium into the stratosphere, unused and unsung, and can deposit it to where it will be loved, nurtured, and appreciated.

Sorry for the ramble through the bramble. Wishing everyone sunshine and roses.

Cheers!