@irenea8 If you read through this thread and others related to Brinsupri (which I encourage you to do) you'll find that everyone is different, experiencing subtle differences after 2 weeks to significant symptom relief after 4+ months, and a lot of points in-between. Even without the drug people with BE produce different amounts of sputum everyday. No 2 days are alike. Remember, Brinsupri takes up to 6 months to "work". Hope it does for you!

@irenea8 I am currently in my ninth week, no side effects. In my case the improvements have been very subtle, but consistent. By week five, it dawned on me my cough was better, and my mucus both thinner and diminished. My air clearance daily became easier. By week seven, again subtle,my fatigue was lessening. When I use my start date, Dec 4th as a benchmark….its more revealing. When I compared my slow treadmill workout then, and daily step count from then to now both are very much improved now! Before Brinsupri I’d have one or two manageable days a week, and the rest pretty rough. Now( since week five) the days are consistent, with only a rare bad day occasionally.I’m encouraged for even more improvement in the weeks ahead.Hope this helps, and good luck on this journey. Jeanne

@irenea8 Dr. Anne O'Donnell speaking on Brinsupri at the North American Bronchiectasis and NTM Conference.
Not sure if this was posted elsewhere.
Dr. O'Donnell did address the time factor of when to expect to see changes/results for it working.