Prostatitis after Brachytherapy

Posted by ken1969 @ken1969, Feb 2 9:52am

I had a low grade prostate cancer, but an enlarged prostate. In order to have Brachytherapy I had three months of androgen deprivation which shrank my prostate by almost half, after which my urine flow was quite fast, however I still get some "hot flashes 6 months on. After Brachytherapy late Sept, 2025 my urine flow requires straining to start (at night and in the morning). I quit flo-max because it dried our my mouth and interfered with my sleep (not to mention killed my already dampened libido) I suspect prostatitis, but would be interested in comments.

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You really need to speak to your RO about this; prostatitis from BPH is very different from that caused by radiation.
And any treatment is going to be based on that.
I have heard some on this forum say that they required TURP before definitive cancer treatment due to urinary issues which radiation would only exacerbate; this procedure is long lasting.
However, 3 mos of ADT is a short term reversible treatment so whatever underlying BPH issues you had before brachytherapy would probably return.
You have to find out if you can have any kind of intervention at all on a previously radiated (seeds in place?) gland. Best,
Phil

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Curious as to which ADT you had that shrunk your prostate almost by half in just 3 months?

Yes, it’s not uncommon that with drugs like Finasteride, a “shrunk” prostate will improve urine flow.

Also yes, one of the concerns with brachytherapy - depending on its proximity to the urethra - is urinary bother.

Have you been diagnosed with prostatitis? There are a number of treatments depending on what type.

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One of radiation side effects is scar tissue formation in urethra (urethra stricture) that can have similar symptoms, although it is usually evident as "late toxicity" (year or more after radiation).
It is best that you discuss those symptoms with your RO and check what is going on.

Wishing you fast resolution of this problem.

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Profile picture for brianjarvis @brianjarvis

Curious as to which ADT you had that shrunk your prostate almost by half in just 3 months?

Yes, it’s not uncommon that with drugs like Finasteride, a “shrunk” prostate will improve urine flow.

Also yes, one of the concerns with brachytherapy - depending on its proximity to the urethra - is urinary bother.

Have you been diagnosed with prostatitis? There are a number of treatments depending on what type.

Jump to this post

@brianjarvis the shot I got was Leuprolide and then there was a complimentary pill that I took for 90 days (Lupron? can't find that for sure) I have a follow up with my radiation oncologist in a couple weeks and have made an appointment with a urologist also at that time. I have not been diagnosed with prostatitis , but the symptoms match up and it's top of my list at the upcoming appointment. I have considered talking to my local GP, but they are sometimes reluctant to step on other Dr's turf.

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Profile picture for brianjarvis @brianjarvis

Curious as to which ADT you had that shrunk your prostate almost by half in just 3 months?

Yes, it’s not uncommon that with drugs like Finasteride, a “shrunk” prostate will improve urine flow.

Also yes, one of the concerns with brachytherapy - depending on its proximity to the urethra - is urinary bother.

Have you been diagnosed with prostatitis? There are a number of treatments depending on what type.

Jump to this post

@brianjarvis OK, found it! One infusion of Leuprolide followed by 100 days of bicalutamide.

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Profile picture for ken1969 @ken1969

@brianjarvis OK, found it! One infusion of Leuprolide followed by 100 days of bicalutamide.

Jump to this post

@ken1969 Yes, Leuprolide is the active ingredient in Lupron (as well as in the ADTs Eligard, Prostap, Camcevi, & Lucrin).

The symptoms of prostatitis and UTI can sometimes similar; they’ll know what to look for.

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Western Radiation Oncology is a high volume brachytherapy (BT) center. They specialize in low dose brachytherapy (LDR), i.e. the permanent implantation of radioactive "seeds" that deliver their radiation dose over a period of weeks to months. They have a webpage up on how to manage side effects from LDR
https://westernradiationoncology.com/how-to-manage-urinary-side-effects-of-prostate-cancer-treatment/
Quoting from the webpage: "The silver lining is that for most men, urinary side effects from prostate radiation are temporary and manageable. They often start to subside within a month or two after finishing therapy, especially with the measures described above. As time passes, you should notice gradual improvement in frequency, urgency, and comfort. Many men return to their baseline urinary habits within 3–6 months post-treatment, if not sooner. Every patient is different, though – if you had pre-existing urinary issues (like an enlarged prostate causing slow flow) those might take a bit longer or require ongoing management."

If you had high dose brachytherapy (HDR), i.e. a one or two visit procedure where a highly radioactive source is temporarily run through tubes placed in the prostate, that pauses for short periods in various spots, that is removed after the procedure, the side effects tend to develop more rapidly and decline faster than with LDR.

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