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How can I reduce high cholesterol from AIs?

Breast Cancer | Last Active: Jul 2 1:23pm | Replies (16)

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I am 71 and have been taking letrozole an AI since last April. I have been taking a good quality red rice yeast for many years with good success. I am primarily vegetarian but eat fish and lots of grains, vegetables, beans and nuts and fruit. I exercise and lift weights. I recently met with a cardiologist/oncologist who did more in depth blood work to look at the size of the LDL blood cells - so more details about them carrying plaque to my heart. My total cholesterol was 204, the LDL was 122 and the HDL 63 and the triglyceride was 90. I had a calcium score of 19. I have a family history of congestive heart failure and arrhythmia issues. I live in atrial tachycardia and sometimes afib - 4 ablations haven’t addressed the issues. So I am on a beta blocker metoprolol and eliquis. This new cardiologist put me on Lisinopril to ease any burden on my heart since my echo with strain showed a slightly low ejection fraction of 45-50 instead of 50-55. Now because of the bloodwork she wants me to take a statin. She said my my LDL should be under 70 and because I live such a healthy lifestyle already and am already taking 1800 IU of red rice yeast, this is important to take a statin. I am so fearful of side effects. But I know the AI can increase your cholesterol and I don’t want to have plumbing cardiac issues. I have another 4 years and three months on letrezole. I am torn about what to do and was leaning against taking them but my family and other medically knowledgeable people are urging me to try them to see what happens.

I am so relieved to hear that I am not the only person who doesn’t want to take them. It is bad enough that I had breast cancer. Now the treatment is creating other issues which require new treatments? I feel like it is all too much.

So my question is for those of you taking statins how long did it take to have issues? Do you know anyone who hasn’t had muscle aches? I already have joint pain from the AI. How can we distinguish which drug is causing what issue?

Has anyone seen a physician that looks at everything and helps you determined how to proceed?

My oncologist and rheumatologist also wanted me to take prolia and I said no to those drugs too. I am lifting weights and taking Algie cal plus and eating more bone healthy foods.

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Replies to "I am 71 and have been taking letrozole an AI since last April. I have been..."

@wews just saw this but I was put on statin due to elevated levels (of everything) before the breast cancer. I started to show mild symptoms at about 6 weeks that I didn’t really correlate to the statin. Just muscle cramps. Got really bad by 3 months - every night between midnight/12:30 would get horrible cramps in my legs - get up and walk and stretch for 20 minutes or more to even begin to get relief. But by that time, I was going through treatment - had surgery and prepping for radiation when oncotype came back positive and had to decide on chemo. Talked to brother and mentioned this and he suggested it could be the statin (he’s tried every one there is and couldn’t take them). Stopped and within 48 hours all the cramps stopped, in a few weeks, even with the chemo, I was stronger. But Dr wanted me back on so I did and after a month ended up at cardiologist because of problems which turned out to be the statin. So stopped and refused anything else (recc was Zetia). Started berberine because next bloodwork showed elevation in ldl and borderline A1c. 6 months later all were normal even on the Anastrazole. LDL went up to 125 on exemestane but my reading indicates it will happen and as long as mild, doesn’t need treatment and will normalize once off the ai. So I’m holding (now at 115) without treatment.