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BHRT vs PHRT

Osteoporosis & Bone Health | Last Active: Feb 21 10:43am | Replies (47)

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@kathleen1314 Thanks for that helpful information!

I may take Strontium Citrate but am hanging back for now. Research done on Strontium Ranelate shows enticing bone improvements.

But research articles say that strontium makes un-adjusted DEXA scans appear to show more calcium than you really have, and hence falsely more bone strength. I am not ready to commit to possible future explaining that to an insurance company if I want them to approve some other OP treatment. Estimates are that strontium stays in your bones for 10-30 years so it is a big decision.

Here is an example technical article that discusses adjustments that should be made to T-Score readings to get estimates of what bone strength really is when one has taken Strontium.
https://onlinelibrary.wiley.com/doi/10.1359/JBMR.050810
Excerpts:
"Without an appreciation of the effect of introducing a high atomic number element into bone on the measurement process, many will take the impressive increases in BMD in strontium-treated patients at face value."
"... much of the strontium present in bone at the end of treatment is likely to still be there a decade later. ... and a final terminal exponential with a half-life of ∼30 years."

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Replies to "@kathleen1314 Thanks for that helpful information! I may take Strontium Citrate but am hanging back for..."

@kfhoz
I can understand concerns over taking any osteoporosis treatment without the research needed to make you feel secure in your decision.

Just some information about concerns which you have raised about strontium citrate.

You say:"research articles say that strontium makes un-adjusted DEXA scans appear to show more calcium than you really have, and hence falsely more bone strength."
To clarify: Research has analyzed dexa machines and finds that strontium skews about 10% denser due to its denser nature; it is not correct that it shows more calcium; it does skew about 10% denser; it does not falsely show more bone strength.
https://pubmed.ncbi.nlm.nih.gov/20699129/
TBS reports, which are not affected by strontium the way dexa is, show strontium bones with good bone quality and in the top group of osteoporosis treatments (see attached bar graph from the research). REMS also shows good bone density and bone quality for strontium patients, are per self reporting. Hopefully, a study will be done in the future. The best report we have so far is one done on TBS. A report which shows strontium in the higher level of bone quality. (see attached bar chart) plus Page 7 in linked below
https://www.panoramaortho.com/wp-content/uploads/2019/03/TBS-Review-JBMR-2014.pdf
The research which you hotlinked is from 2009. Much of that information is useful, but because of its age much of it has been rendered moot because of tests like REMS and interpretation methods like TBS, neither of which were available in 2009. Both of these, REMS and TBS, have laid to rest the old, dexa skew concerns, because they both show good bone quality and bone density for strontium users.
Indeed, I just had a DEXA with TBS which showed good bone quality and normal/good bone density. I have been taking strontium citrate since 2009.

The concern about strontium being present in the bone after treatment is actually a plus. Other osteoporosis drugs, specifically bisphosphonates (like alendronate, risedronate, and zoledronate), remain in the bone for years or even decades after treatment stops. They accumulate in the bone matrix, creating a reservoir that continues to provide anti-fracture benefits for 1-2 years or longer, allowing for a "drug holiday" after 3-5 years of use. Strontium also stays in the bone and creates what one report calls "sacrificial bond formation" that correlate to reduced fracture risk. In other words, strontium seems to work mainly because it changes the physiochemical relationship in bone to allow bone the ability to absorb shock and dissipate instead of break....give instead of break. Section 4.2
https://www.sciencedirect.com/science/article/pii/S2352187220300334
Strontium Citrate holds a unique position in the world of osteoporosis medicine between supplements and osteoporosis drugs. It is virtually side effect free and may be begun easily or ended easily without problems. It can cut the risk of fracture around 41 to 49%; it is found to improve bone quality on the comparable level to Prolia and Forteo without the side effects which those drugs have. (see attached bar chart and above linked research)

Also, there was the amazing research done using biopsies of bones, those of a placebo group and those of strontium users. The biopsies showed good bone density and quality. (See attached photo with the link to the research)

The treatment which we choose for our osteoporosis is a uniquely individual decision. It is not just made up of logic, there is a component of emotion in finding something with which we feel comfortable. I try hard not to downplay anyone's choice of treatment. There are lots of good treatments for osteoporosis, and I frequently point people towards information and people who know more than I do about osteoporosis pharma drugs. I honor and do not demean anyone's choice of treatment. We all have to decide what is best for us and rejoice when that treatment works for any of us.

Strontium Citrate works for me, and I am enormously grateful that I found it.