← Return to Kevzara (sarilumab) to treat PMR

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Kevzara (sarilumab) to treat PMR

Polymyalgia Rheumatica (PMR) | Last Active: Feb 10 7:53am | Replies (187)

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@elleninz

That 28% success rate depends on how you define success. The people enrolled in the study trial were said to have at least one PMR relapse during a Prednisone taper. The patients enrolled in the study were the ones who failed to achieve remission with the standard treatment with Prednisone. One could say that "Prednisone failed" these patients. Improvements were highest in patients with the most severe disease.

People are inclined to say that taking Prednisone is about "quality of life." My quality of life improved immensely when a biologic allowed me to taper off Prednisone.
https://pubmed.ncbi.nlm.nih.gov/40544861/
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The following link summarizes the actual SAPHYR study.
https://pubmed.ncbi.nlm.nih.gov/37792612/study.
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Patients who didn't have "success" with Kevzara needed substantially less Prednisone to control PMR. That in and of itself is deemed to be a success by medical professionals.

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Replies to "@elleninz That 28% success rate depends on how you define success. The people enrolled in the..."

@dadcue
Hi. Thank you for the information and links. Just went to rheumatologist on Friday, she is putting in the orders for Actemera as I show GCA on the aorta . We will see. Very hopeful.
Ellen D