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CAR-T Cell Therapy: Introduce yourself and connect with others
Bone Marrow Transplant (BMT) & CAR-T Cell Therapy | Last Active: Feb 9 9:35am | Replies (360)Comment receiving replies
I’m just connecting with this discussion which I see took place six years ago! I did a CAR-T trial in January for stage 3 ovarian cancer. First, four days of chemotherapy to knock out my immune system, then the actual infusion of my modified T cells two days later. I experienced low level CRS although it didn’t feel low level: fever of 101.9, vomiting, intense shaking. Two and three days later I had injections of interleukin (IL-2) which caused more inflammation, intense bone pain and a generalized rash. Now three weeks post infusion and just starting to get some energy back. I’ve had significant mental fogginess which has made it difficult to read or do much, but that is starting to clear. Personally, this was much more difficult to go through than front line chemotherapy, however I have no regrets. I will have CT scans in two weeks and that will show the outcome…nervous about this.
Replies to "I’m just connecting with this discussion which I see took place six years ago! I did..."
@amywells Welcome to the CAR-T group! CAR-T cell therapy has been rapidly gaining ground in the treatment of various types of cancer, including ovarian. That’s a huge breakthrough. And while you found the initial side effects a bit more challenging than the frontline chemo you had for your cancer treatments, this CAR-T procedure may help ensure that you will no longer have to worry about the cancer or any more chemo.
Wishing you well on your recovery! I think you’ll be encouraged with comments from @kirkwilliams2049 @aalietz @4health4bonnie and others who have shared their success stories with their CAR-T journeys.
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@amywells
Wife had CAR-T therapy for DLBCL in her brain stem in May 2025 after 4 Chemo treatments of methotrexate and 2 immune suppression chemos in preparation for for the CAR-T infusion. She had a low grade fever for a few days and her most troublesome side effect was the “brain fog” you experienced. This has improved with time (now 7 months out) and is no longer an issue.
She remains in remission with now indications of a mass after 3 brain MRIs and is feeling excellent!
We are very thankful that our Oncologist at the Abramson Cancer Center in Philadelphia prescribed this treatment.
We wish you similar success!