@brooklyn22 I hope I can explain what I know. You should ask your oncologist for the percentage of risk reduction for the Aromatase Inhibitors with your specific cancer. Let's say there is a 50% improvement with the drugs. But then you need to know what you risk of recurrence/spread actually is. Let's say it is 2%, so the risk reduction is very minor. But if it is 80% the risk reduction could be critical. As I'm no doctor I don't know the exact answer--but your oncologist should provide you with the info you need. It will vary person by person. Also, consider if you re ok with starting an Aromatase Inhibitor and seeing how you do. (I think from your comments you have not yet started?) You can always start and then tell your oncologist you are stopping--or ask to try a different one. I gather about half of women have few or no problems. I've been on letrozole for 3 1/2 years without side effects and good cancer control. I hope you can get some peace mind with this decision. (I found decision making the hardest part, for me, of the process).