@newyorkgirl May I cheat. And share real use of special K? I had 7 Ketamine treatments over about 10 or so days. All was done under the direction of an AZ licensed Doctor (MD) & assistants. He never left me once during any session with the wonder drug. Sure I was depressed. Hell if I know.. Perhaps TRD. Nothing ever lifted the veil. Multi-Med Tries, Acupuncture, CBT 40 hours, Giving a Shit; nada. About then the medicine show brought K to town. Even some TV News Doctors didn’t outright call for a kick bucket. Me? Hey, I had smoked 2 cigarettes at age 18 and never another. Alcohol? Yeeaaah, until about 30. But never used crap. But THIS was FDA approved crap, so it must be okay - maybe even HELP. My wife backed me up when not fretting. Met the doctor. Nice smile. Explained it all to us. My doctor? Oh, yeah, Tatyana, APRN, NP, PMHNP-BC. Yeah, she’s totally down with it.
The day came. Was taken into a swank exam room, waiting for the man. Glanced at a medical book whose one word title I didn’t understand, except not giddy about its first two letters: EU. While infused I felt rolled around like a roller coaster. Ambient light changed color often. Never nauseous mildly dizzy. Felt like I should have been “belted in” my chair. Had my height measured just to be sure NEVER a user of illicit drugs, even pot, I cannot compare it to anything substance it might have mimicked. Perhaps a “user” could have, perhaps not. The session over and the “ride” having come to a stop, I sat for awhile and spoke briefly with the Dr. Not much said. My wife drove us home, I certainly would have at least swerved or worse, had I tried to drive. I did not feel “sick” but certainly not steady , nor would have passed sobriety test, I think. In the car my wife & I spoke of the event - I just a little as I felt I needed to steady my senses. Got home, lay down on our bed, rested - may have dozed off 1/2 hour. Then pretty much back to self. Wife stayed of course. AS for changes in mental status or neurological control I noticed no difference. Let’s say, in general there was no nuanced “high”, no creeping vigor in my body, no change of customary doleful mood, no welcomed spark of deliverance on the horizon. But then that had been the first go-round. Six more lay ahead.
But after the 6th, the last, I didn’t even want to volunteer. Bless my wife. And my Service Sloth.

@newyorkgirl I went from Sertraline to Pristiq last spring. I didn't notice any change when I went on, or when I went off.