For those who take Creon - how do you determine how much to take with each meal? My GI doc prescribed two capsules with meals and one with snacks. I take the 36,000 unit capsules, weigh about 135, and I also have collagenous colitis so my symptoms overlap. My meals average about 450 calories and usually have a snack in the evenings that runs about 200 calories. I split the dose during meals - taking one at the start of the meal and one about halfway through. For several months my symptoms were controlled but over the last 6 months I have started having diarrhea again that does not appear to be related to anything. I was placed on a higher does of Budesonide, which briefly helped. I have contacted my GI for further instruction and in the interim am doing my own research - and wondering if I should try increasing my Creon dose. What has your experience been?