@leslieb52 on Prolia for 3 years and only appeared about 6 months ago. The doctors still not convinced it was from the prolia so lets hope not. Yes I do think Prolia can make you feel more tired and it is listed as a side effect. I've just started taking vitamin B6 and have actually been sleeping better as I was feeling very tired. I'm fine if I sleep ok but I think I haven't slept well since I've been taking pravastatin for high cholestoral. I also tend to do a lot of exercise and maybe over exercise at times. Just have to take a bit of extra care of ourselves when on any meds and I don't want to blame the Prolia for everything which is what we may try to do. I decided to try B6 as I'm not a huge eater and only weigh 47kg