Differentiated Liposarcoma: What treatments have you had?

Posted by sids @sids, Aug 23, 2025

A few weeks ago I was diagnosed with Differentiated Liposarcoma which seems to be a very rare cancer, I am having a hard time researching for related information. The MAYO team have been great to do the needed tests. The Mass has grown and attached to the colin and bladder and surrounded the main blood vessel that sends blood the the leg and foot so surgery is not an option. I am also told chemo is not option in my case so we will be looking at radiation.

If there is anyone out there that has this Liposarcoma cancer I would appreciate hearing from you and learning about your life with this cancer. Are their other alternative treatments that anyone is aware of?

Interested in more discussions like this? Go to the Sarcoma Support Group.

Profile picture for reyaz1997 @reyaz1997

My mother has been suffering from dedifferentiated liposarcoma (retroperitoneal mass) and she was operated in 2023 and the tumour was removed with negative margin and again in 2026 reccurance of the tumour happened and some doctors saying that first they will give chemotherapy to reduce the size the tumour and then they will operate. But some doctors saying that they will operate without giving chemotherapy but they have to remove some parts of the colon and pancreas because tumour is attached with that. So I am confused what to do. Please help if any one have idea about that.

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@reyaz1997
Hello.....many surgeons want to reduce the size of the target tumor to make the surgery more manageable, and possibly a better outcome. The tradeoff being the extra burden of side effects of the chemo before surgery. You should have a clear understanding of those side effects, as well as what the surgeons expect from the chemo and how certain they are of "success" with all that. Also important is your Mom's age, relative health and stamina, and her willingness to tolerate chemo, before a major surgery. For the "surgery alone" option, given it may be a larger area to remove without chemo, the impact on the organs affected and the affect on your Mom's quality of life should be weighed. Also, what are the potential complications of surgery alone? Each choice has it's own significant impacts on your Mom, so hopefully each Dr should be able to give you more information regarding those impacts before your Mom decides on the course to take. Best wishes for a successful outcome!!

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Profile picture for reyaz1997 @reyaz1997

My mother has been suffering from dedifferentiated liposarcoma (retroperitoneal mass) and she was operated in 2023 and the tumour was removed with negative margin and again in 2026 reccurance of the tumour happened and some doctors saying that first they will give chemotherapy to reduce the size the tumour and then they will operate. But some doctors saying that they will operate without giving chemotherapy but they have to remove some parts of the colon and pancreas because tumour is attached with that. So I am confused what to do. Please help if any one have idea about that.

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@reyaz1997

I had sarcoma, and my treatment path was both chemo and radiation before surgery. For what it is worth.

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Profile picture for amelieonsoti @amelieonsoti

@colleenyoung
No dad has had no radiation. His liposarcoma tripled in size following the biopsy. Prior to the biopsy the lump had been growing slowly over a period of a year and he had no pain.

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@amelieonsoti my husband has the same lipo sarcoma, he has had it recurring since 2016 and every time he had a biopsy don’t it triples in size within two weeks or less.

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