On Anastrozole just over a year and half. Age 73, active/healthy, other than my "decades old breast cancer" returning in my lymph nodes. The Anastrozole really did its job - reduced the cancer size so they could do surgery - then had 16 rounds of targeted radiation. My oncologists pushed for Chemo then CDK but I declined due side effects and my age - they did recommend ZOMETA infusions every 6 weeks - not for osteoporosis but to prevent this cancer from metastasizing in the bones - this month will be getting a second infusion. This biggest problem is that AI's are hard on your heart, bones and also can be associated with dementia. Personally will stay on Anastrozole no more than 2 years unless they find my cancer is coming back which my oncologists seem to think is likely. Unfortunately oncologist offer only solutions that poison or made us weaker and more susceptible to other diseases - especially if we are in the "elderly" category. I am keeping close tabs on ANKTIVA/BioShield and hopeful the FDA will approve for ALL CANCERS - this treatment alone or with other cancer drugs like Chemo are strengthening cancer patient's immune system/NK cells - successful for bladder, brain and lungs cancers. This make sense - all cancer patients need to ensure they are checking their ALC levels - your lymphocyte count should be above 1000. Only 4.6% of patients with lymphocyte counts under 1000 were alive 4 years after surgery compared to 23% with lymphocyte counts above 1000. Old age, chemo, radiation all reduce lymphocytes. I am hoping to hold off my cancer and the destruction of my health with traditional cancer drugs - optimistic ANKTIVA will finally become available for all cancer patients and we will be allowed to strengthen our own immune system NK cells.