You should have received some paperwork in the box you received with your Kevzara , the one that has all the fine print. You can also see it on the Kevzara website under “ Prescribing Information” In there it says that Kevzara is to be refrigerated! Never frozen. Mine always came in a styrofoam cooler, wrapped in a bubble wrap and stuffed with frozen reusable ice packs and shipped by FedEx. Overnight. And when I received it I put in immediately in the refrigerator. The night before I would take it out for the next morning. If I would have received it warm from the pharmacy I would not accept it or use it. Mine came from a specialty pharmacy. Call Kevzara 1-844-KEVZARA (538-9272) for your questions.