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Transdermal HRT

Osteoporosis & Bone Health | Last Active: Feb 18 7:13pm | Replies (298)

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Profile picture for mcchesney @kathleen1314

@wondering1
In some cases of extremely high progesterone may cause breast tenderness due to fluid retention, but usually this is a side effect of estradiol which produces a sharper tenderness contrasting with the heavy swollen feeling of progesterone overstimulaton.
But....
Since you began to bleed after you changed your progesterone to a cyclical schedule that leans towards the idea that your estradiol is too high or you are sensitive to estradiol.
Estriol might be a better match for you with the progesterone reinstated at a lower level if the hormone tests indicate a need to actually lower progesterone.

How is your doctor checking your hormone levels? I ask because topical hormones will not show in serum testing accurately. For topical hormones you will need a saliva test.
AI Overview, based on the current practices and research which it analyzed:
Saliva testing is considered superior to serum (blood) testing for monitoring topically applied (transdermal) bioidentical hormones because it measures the bioavailable, free hormones that have entered tissues, whereas topical hormones often do not show up accurately in blood serum. Topical hormones, particularly progesterone, tend to accumulate in subcutaneous fat, making saliva a more direct reflection of tissue absorption and reducing the risk of over-dosing.
\https://coyleinstitute.com/saliva-testing-vs-blood-testing-for-hormone-levels/#:~:text=In%20the%20body%2C%20almost%20all,use%20by%20tissues%20and%20organs.

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Replies to "@wondering1 In some cases of extremely high progesterone may cause breast tenderness due to fluid retention,..."

@kathleen1314 , thanks for your thoughts on this! All my levels are being checked via blood tests. I'm taking estradiol via the patch...does that count as topical? My progesterone is oral.

The breast tenderness really seems to be linked to progesterone. When I lower progesterone dose, the breast tenderness gets better. My provider says based on my blood levels, I seem to take up progesterone at a higher rate than she sees in most of her patients.

My provider has been looking at the ratio of progesterone to estradiol and wants my progesterone lower compared to estradiol. In researching this ratio, I've been unable to find anything much on an ideal ratio. Dr Doug Lucas does mention it, but I haven't seen it anywhere else. Do you know of any research related to this?