← Return to Anyone had salvage radiation therapy post-prostatectomy?

Discussion
Comment receiving replies
Profile picture for soli @soli

I’m currently on BCR watch after prostate surgery last September. If and when I have a recurrence, I’ll need salvage radiation, so I’ve been doing a lot of reading and recently consulted with Dr. Amar Kishan, a leading radiation oncologist at UCLA.

He’s doing important work on improving the precision of radiation delivery, including real-time adjustments during treatment—such as pausing radiation if nearby organs move beyond a preset limit, and reducing planning margins. The goal is to better protect surrounding organs and reduce side effects.

One key takeaway from my discussion with him is that radiation tends to worsen pre-existing urinary symptoms, such as urgency, frequency, and post-surgical incontinence—especially in patients like me who already have these issues. Because of that, SBRT (which is currently only available post-prostatectomy as part of a clinical trial for salvage radiation) may carry a higher risk of side effects for some of us compared with conventional salvage radiation given over 35–40 treatments.

Bottom line: side effects depend heavily on the experience of the treatment team, the precision of radiation delivery, and a patient’s pre-existing urinary (or other) issues.

Jump to this post


Replies to "I’m currently on BCR watch after prostate surgery last September. If and when I have a..."

@soli
I'm simply replying to the most recent contribution to this thread, but it has been on my mind in deciding on any radiation therapy. From the MiraDx company:

"PROSTOX test can report the risk of late GU radiation toxicity from stereotactic body (SBRT) or conventionally fractionated (CFRT) radiation therapy, based on a patient's mirSNP signature. The assays provide a high or low risk score that may be useful in choosing the safest course of treatment, to avoid toxicity."

"High-grade GU (genitourinary) toxicity after SBRT can occur years (5 to 10) after radiation treatment. Cumulative Incidence: Grade 2 or higher GU toxicity has been reported as 16.3% by year 5 and 19.2% by year 10.
Types of Toxicity: Common late toxicities include worsening or new urinary incontinence, hematuria, and urinary urgency." (AI or search results)

Is this ever offered to patients like us? I have yet to have this type of discussion with a Radiation Oncologist.