Welcome @save4forever, Sorry to hear that you are having the neuropathy pain symptoms in your hands after taking the Zepbound injections. You can report the side effects to Medwatch - - https://www.fda.gov/safety/medical-product-safety-information/medwatch-forms-fda-safety-reporting. @projfan reported similar side effects and may have some suggestions.

Have you talked with your doctor about the side effects and/or reported the side effects to Medwatch?

@save4forever Congratulations on identifying this and taking action! Agree with @johnbishop that reporting to MedWatch is action we can all take to help other people in the future.

What to do next to help yourself depends on your specific situation. Time and distraction may cause the symptoms to fade. If you do not have experience with chronic (rather than acute) pain, you may not have discovered that it can get worse when you focus attention on it and better when you focus attention on other things -- welcome to your brain at work. So the more you can get fully engaged in work or play or social engagements, the better.

At the same time, you may want to talk with your doctor about whether there might be more than one trigger for the pain, and something you can do to address those triggers. In my case, I've cut vitamin B6 from all the supplements I take. In your case, you might want to check for osteoarthritis in the hands, for example.

There are tests that can be done for other sources of PN as well. If yours continues to progress -- the pain or other symptoms get worse, or move up from your hands into your arms -- you may want to get a referral for those tests. Some of those other sources of PN are more treatable than DIPN.

Finally, if the pain in your hands is getting in the way of living your life, you may want to consult with a physical therapist for targeted exercises or an occupational therapist for workarounds. Make sure these are people with PN experience. In fact, you might want to get a referral from an oncologist, since most DIPN is related to taking cancer drugs, so oncologists are the folks with experience here.

Having said all that, there's still the matter of dealing with whatever caused you to start zepbound in the first place. Presumably, that problem has not gone away. You can try other drugs or forms of GLI-1 RAs (I'm now on a very low dosage of Ozempic). Or you could explore bariatric surgery, keeping in mind that you can stop that exploration at any point, and having an initial consultation is not making a commitment.

If you are like me, and have been gaining and losing and gaining and losing weight for decades, you've tried all the other lifestyle options, so drugs and surgery are pretty much what's left.