@songinmyheart54: I have not heard of that lifetime protocol. The one I am familar with is a 2 year max duration as there has not been any proven benefit in continuing longer; should metastasis return, restarting or escalating to dual therapy can be considered.

If you're having untoward side effects and are curious about the protocol your doctor has you on or about alternatives, you may want to reach out to AIM Melanoma Talk to An Expert. This is a globally recognized foundation aimed at finding effective treatments for melanoma; Melissa Wilson PA-C is excellent at answering submitted questions totally free of charge. She has helped me considerably when I've needed some additional direction. You simply enter your question here: https://www.aimatmelanoma.org/support-resources/talk-to-a-medical-expert/ and select the method for a return response, for example a phone call or email.

Do you think that would be helpful?