@brooklyn22 I'm no expert, but I believe knowledge is power. First, the onco score indicates whether or not chemo will be helpful. That's it. (Maybe you're thinking of your Ki-67 score, which measures growth rate?) But either way, you're wise to be exploring all options before making a decision. Yes, low-dose (10 mg) Tam is currently being evaluated in trials & my oncologist believes research is leaning toward approval. It also protects bones. Hope you find a good solution that works for you! We each have to find what we're comfortable with, giving our bodies the best chance.