← Return to Recurrent UTIs After Hysterectomy: When antibiotics don't work?

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Profile picture for Helen, Volunteer Mentor @naturegirl5

@kisu Thank you for these suggestions. Since @chigal10 had uterine cancer she may not be able to use any estrogen products.

@chigal10 If I may ask, what kind of uterine cancer was diagnosed? There are different kinds of uterine (endometrial) cancers such as

Endometrioid carcinoma
Serous carcinoma
Clear cell carcinoma
Undifferentiated carcinoma/ Dedifferentiated carcinoma
Mixed carcinoma
Carcinosarcoma

Here is a website that describes these cancers.

American Cancer Society: What is endometrial cancer?
https://www.cancer.org/cancer/types/endometrial-cancer/about/what-is-endometrial-cancer.html
If you would like to provide us with more information perhaps we can be more helpful to you. For instance, did your oncologist say anything about whether or not you can use estrogen products as described by @kisu?

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Replies to "@kisu Thank you for these suggestions. Since @chigal10 had uterine cancer she may not be able..."

@naturegirl5 @kisu Thanks for the suggestions and support.

So I had fibroids which fused to my uterus and upon surgery I was diagnosed with endometrioid carcinoma which resulted in the need for a hysterectomy. Luckily they left my ovaries (fwiw.)

I didn’t have any uti issues for a while, up until about a year in. Then I had my first UTI ever. I didn’t know what it was at first because I never had one so I had nothing to compare it to for reference.

Then I went back to my oncologist, thinking it was something related to my surgery such as a cuff issue.

However, it wasn’t and they ran a urine culture to find Ecoli and I was put on Macrobid which cleared it.

I’ve been taking cranberry supplements and D-mannose and using a sterile lubricant during sex called slippery stuff, which is sterile water-based lubricant. In addition to doing pelvic floor physical therapy.

Things seemed to be going all right until about February of last year 2025, when I developed another UTI out of nowhere.

After that was cleared up, I tried estradiol cream. I felt like that was helping my symptoms a little in terms of dryness and pain, but then unfortunately for me 2 weeks or so into using that I developed a yeast infection and then subsequent UTI. I’m not sure if they’re related to the cream use or not.

Now that I moved to Minnesota I’m in the process of finding all new doctors. I did already meet with a menopause specialist, and I’m hoping that will be a good fit.

She recommended trying an extremely low dose of estrogen via vaginal tablet method, which I have not done before.

I’m willing to give this a try but I’m still extremely nervous that I’ll develop a yeast infection or uti.

I also have to be very careful with any hormone therapy— even a low dose because I suffer from epilepsy and my seizures are triggered by hormones. So a urogynecologist has to work in tandem with my neurologist to try to create a treatment plan that works well for me, which is not easy.

To add insult to injury, I’m also progesterone sensitive. So in theory progesterone HRT can actually help reduce some seizures; as it’s usually estrogen that triggers seizures. That’s really my main hurdle rn.

It’s incredibly emotionally and physically stressful. 😥